MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a 16-amino-acid peptide encoded within the mitochondrial genome. It is the first mitochondrial-derived peptide shown to regulate metabolic homeostasis at the cellular and systemic level. Research has demonstrated its role in activating AMPK signalling, improving glucose uptake and insulin sensitivity, and mimicking certain metabolic effects of exercise. Studies in aged mouse models have shown improvements in physical performance and metabolic markers. It represents a novel class of retrograde signalling molecules from mitochondria to the nucleus. Each vial contains 10 mg at ≥99.0% purity.
Category: Metabolic
Purity: ≥99.0%
Quantity: 10 mg per vial
Format: Lyophilized powder
Reconstitute with 1-2 mL of bacteriostatic water. Swirl gently until clear.
Store lyophilized powder at -20°C. After reconstitution, refrigerate at 2-8°C and use within 30 days.
Ships from Chilliwack, BC via Xpresspost. 2-3 business day delivery. Discreet, insulated packaging.
MetaboLab
May 26, 2026
AMPK activation confirmed in our cell line. Purity checks out on mass spec.
D. Huang
May 11, 2026
Few Canadian suppliers carry MOTS-c. Quality is excellent — glad I found PepSupply.
FitResearch
Apr 27, 2026
Good product for exercise mimetic studies. Glucose uptake data is consistent with literature.
Dr. J.B.
Apr 9, 2026
Mitochondrial-derived peptides are the future. Great to see a Canadian source with proper QC.
E. Santos
Mar 19, 2026
Second order. Insulin sensitivity assays showing clean dose-response. Reliable supplier.
CellBio_AB
Mar 4, 2026
Reconstituted clear. Our metabolic panel results align perfectly with published studies.
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